Non‐syndromic cleft lip with or without palate‐susceptible SNPs is associated with hyperdontia

Background Non‐syndromic supernumerary teeth (NSST) or hyperdontia may share common genetic determinants with non‐syndromic cleft lip with or without palate (NSCL/P). The aim of this study was to test the associations between five genome‐wide‐associated NSCL/P‐susceptible single nucleotide polymorphisms (SNPs) (rs2235371, rs7078160, rs8049367, rs4791774, and rs13041247) and the occurrence of NSST. Materials and methods A total of 163 cases and 326 controls were recruited and their genomic DNA was extracted from blood samples. Five NSCL/P‐susceptible SNPs (rs2235371, rs7078160, rs8049367, rs4791774, and rs13041247) were genotyped by TaqMan method. Odds ratio (OR) and 95% confidence interval (CI) were used to estimate the associations between the SNPs and the risk of NSST by PLINK software. Results Rs4791774 (A > G) and rs13041247 (T > C) were associated with risk of NSST (rs4791774: P add  = 0.011, OR, 95% CI = 0.62, 0.43–0.90; rs13041247: P homo  = 0.031, OR, 95% CI = 1.79, 1.05–3.05) and one supernumerary tooth (rs4791774: P dom  = 0.009, OR, 95% CI = 0.56, 0.36–0.87; rs13041247: P homo  = 0.034, OR, 95% CI = 1.82, 1.05–3.15). Rs4791774 (A > G) was also showed association with risk of upper arch supernumerary teeth only ( P add  = 0.010, OR, 95% CI = 0.60, 0.41–0.89). Conclusion Non‐syndromic cleft lip with or without palate‐susceptible loci rs4791774 (A > G) and rs13041247 (T > C) were associated with the risk of supernumerary teeth.