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Non‐syndromic cleft lip with or without palate‐susceptible SNPs is associated with hyperdontia
Author(s) -
Kan Shiyi,
Zhu Guirong,
Du Yifei,
Fan Liwen,
Yang Fan,
Lou Shu,
Li Dandan,
Ma Lan,
Pan Yongchu
Publication year - 2019
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13149
Subject(s) - medicine , single nucleotide polymorphism , dentistry , orthodontics , genetics , biology , genotype , gene
Background Non‐syndromic supernumerary teeth (NSST) or hyperdontia may share common genetic determinants with non‐syndromic cleft lip with or without palate (NSCL/P). The aim of this study was to test the associations between five genome‐wide‐associated NSCL/P‐susceptible single nucleotide polymorphisms (SNPs) (rs2235371, rs7078160, rs8049367, rs4791774, and rs13041247) and the occurrence of NSST. Materials and methods A total of 163 cases and 326 controls were recruited and their genomic DNA was extracted from blood samples. Five NSCL/P‐susceptible SNPs (rs2235371, rs7078160, rs8049367, rs4791774, and rs13041247) were genotyped by TaqMan method. Odds ratio (OR) and 95% confidence interval (CI) were used to estimate the associations between the SNPs and the risk of NSST by PLINK software. Results Rs4791774 (A > G) and rs13041247 (T > C) were associated with risk of NSST (rs4791774: P add = 0.011, OR, 95% CI = 0.62, 0.43–0.90; rs13041247: P homo = 0.031, OR, 95% CI = 1.79, 1.05–3.05) and one supernumerary tooth (rs4791774: P dom = 0.009, OR, 95% CI = 0.56, 0.36–0.87; rs13041247: P homo = 0.034, OR, 95% CI = 1.82, 1.05–3.15). Rs4791774 (A > G) was also showed association with risk of upper arch supernumerary teeth only ( P add = 0.010, OR, 95% CI = 0.60, 0.41–0.89). Conclusion Non‐syndromic cleft lip with or without palate‐susceptible loci rs4791774 (A > G) and rs13041247 (T > C) were associated with the risk of supernumerary teeth.