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World Workshop on Oral Medicine VII: Clinical evidence of differential expression of lncRNAs in oral squamous cell carcinoma: A scoping review
Author(s) -
Pentenero Monica,
Bowers Leah M.,
Jayasinghe Ruwan,
Yap Tami,
Cheong Sok Ching,
Kerr Alexander R.,
Farah Camile S.,
Alevizos Ilias
Publication year - 2019
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13076
Subject(s) - meg3 , biology , differential diagnosis , scopus , cancer , metastasis , bioinformatics , medicine , cancer research , computational biology , pathology , gene , medline , long non coding rna , genetics , downregulation and upregulation , biochemistry
Background Long non‐coding RNA s (lnc RNA s) have important roles in regulating gene expression pertaining to cell proliferation, survival, migration and genomic stability. Dysregulated expression of lnc RNA s is implicated in cancer initiation, progression and metastasis. Objectives To explore, map and summarize the extent of evidence from clinical studies investigating the differential expression of lnc RNA s in oral/tongue squamous cell carcinoma. Methods PubMed, Scopus and Web of Science were used as search engines. Clinical, full‐length, English language studies were included. PRISMA ‐ScR protocol was used to evaluate and present results. The present scoping review summarizes relationships of the differential expression of lnc RNA s with the presence of tumour and with clinicopathological features including survival. Results Almost half of the investigated transcripts have been explored in more than one study, yet not always with consistent results. The collected data were also compared to the limited studies investigating oral epithelial dysplasia. Data are not easily comparable, first because of different methods used to define what differential expression is, and second because only a limited number of studies performed multivariate analyses to identify clinicopathological features associated with the differentially expressed lnc RNA s. Conclusions Standard methods and more appropriate data analyses are needed in order to achieve reliable results from future studies.