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Sex hormone replacement therapy in periodontology—A systematic review
Author(s) -
Chaves João Daniel Paganella,
Figueredo Taize Franciele Massignani,
Warnavin Stephanie Von Stein Cubas,
Pannuti Cláudio Mendes,
Steffens João Paulo
Publication year - 2020
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13059
Subject(s) - periodontology , medicine , dentistry , hormone replacement therapy (female to male) , orthodontics , hormone therapy , testosterone (patch) , cancer , breast cancer
Objective To analyse whether sex hormone replacement therapy (HRT) improves periodontal parameters and dental implants osseointegration in humans. Materials and Methods Electronic databases and hand searches were performed from June to August 2018 in SciELO, LILACS and PubMed/MEDLINE. Human observational and interventional studies that evaluated the following parameters were included: clinical attachment loss (CAL), probing pocket depth (PPD), bleeding on probing (BOP), radiographic bone loss (RBL) or osseointegration. Results Initial search retrieved 1,282 non‐duplicated articles. Fifteen studies were selected after inclusion criteria were applied. All studies were performed in postmenopausal women. Mean differences for PPD reduction ranged from 0.02 to 0.2 mm in HRT‐positive patients; mean CAL gain −0.18 to 0.54 mm; mean RBL reduction −0.87 to 0.15 mm; and mean BOP reduction 9%‐30.3%. Failure rate of dental implants increased −5.5% to 11.21% when HRT was used. Conclusions Very low but consistent evidence suggests a reduction in BOP and no impact on RBL in postmenopausal women receiving HRT. There are inconsistent reports that suggest that HRT in postmenopausal women: (a) improves or does not impact PPD reduction and CAL gain; and (b) does not impact or increase implant loss. In summary, there is no evidence to support HRT prescription for either men or women for periodontal/implant placement purposes.