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NTN1 gene was risk to non‐syndromic cleft lip only among Han Chinese population
Author(s) -
Jiang ShuYuan,
Shi JiaYu,
Lin YanSong,
Duan ShiJun,
Chen Xieli,
Jiao JianJun,
Shen Wei,
Jin Xiaoju,
You Miao,
Wang Moyao,
Shi Bing,
Jia ZhongLin
Publication year - 2019
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.13009
Subject(s) - haplotype , genetics , single nucleotide polymorphism , allele , biology , genome wide association study , gene , linkage disequilibrium , genetic association , medicine , genotype
Objective Genome‐wide association studies (GWAS) found NTN1 , NOG and the region between CREBBP and ADCY9 were risks to non‐syndromic cleft lip with or without cleft palate (NSCL/P). However, the association of single nucleotide polymorphisms (SNPs) in these genes with NSCL/P in Western China is unknown. Subjects and Methods We selected seven SNPs in NTN1 , NOG and between CREBBP and ADCY9 , and then performed transmission disequilibrium test (TDT), parent‐of‐origin effect and sliding window haplotype analysis to test the associations among 302 NSCL/P case–parent trios from Western Han Chinese. Results We found allele G at rs4791774 in NTN1 was significantly overtransmitted among non‐syndromic cleft lip only (NSCLO) ( p = 0.0067, OR = 1.79, 95% CI: 1.17–2.74); rs4791774 and rs9915089 tightly linked with each other among NSCL/P ( D ′ = 0.87, r 2 = 0.67) and haplotypes carrying the risk allele G at rs4791774 were always found to be overtransmitted from parents to cases. Motif analysis indicated that allele G at rs4791774 could greatly alter the affinity of Myc_disc7, so allele G at rs4791774 in NTN1 might modulate C‐MYC transcription to participate in the aetiology of NSCLO. Conclusions Our study suggested allele G at rs4791774 in NTN1 gene is risk of NSCLO, which could greatly increase the risk to have a baby with cleft.