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The association between fecal hemoglobin concentration and oral potentially malignant disorders
Author(s) -
Yen Amy MingFang,
Wang SenTe,
Feng ShengWei,
Lin CheTong,
Chen Sam LiSheng
Publication year - 2019
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12978
Subject(s) - medicine , hemoglobin , cancer , gastroenterology , cohort , population , oncology , biomarker , hazard ratio , confidence interval , biology , environmental health , biochemistry
Objectives The present study was to investigate the association between fecal hemoglobin (f‐Hb) concentration and oral cancer and its precursor, oral potentially malignant disorders (OPMD). Methods We used a population‐based longitudinal cohort study data based on both Taiwanese nationwide oral and colorectal cancer screening programs implemented between 2004 and 2009. The total of 235,234 smokers and/or betel‐quid chewers aged 50 to 69 years free of oral cancer and OPMD at entry were followed up over time to quantify the association between baseline f‐Hb concentration on newly diagnosed oral cancer and OPMD. Results The risk of OPMD increased with baseline f‐Hb in a dose manner, yielding a statistically significant elevated risk of developing OPMD in parallel with the incremental concentration of f‐Hb (adjusted hazard ratios = 0.99, 1,11, 1,07, 1,57, and 1,63 for f‐Hb categories of 1–9, 10–19, 20–49, 50–89, and ≥90 µg Hb/g, respectively, as compared with the reference group (low and undetectable f‐Hb concentrations)) However, there was lacking of a statistical significance for the corresponding association regarding the risk of oral cancer, which is possibly due to sparse cases given a shorter follow‐up time. Conclusion We discovered that f‐Hb concentration was positively related to the risk of OPMD. f‐Hb can be used as a biomarker for early detection of OPMD.