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Anti‐rheumatic medication and salivary MMP‐8, a biomarker for periodontal disease
Author(s) -
Äyräväinen Leena,
Heikkinen Anna Maria,
Kuuliala Antti,
Ahola Kirsi,
Koivuniemi Riitta,
Moilanen Eeva,
Hämäläinen Mari,
Tervahartiala Taina,
Meurman Jukka H.,
LeirisaloRepo Marjatta,
Sorsa Timo
Publication year - 2018
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12930
Subject(s) - medicine , rheumatoid arthritis , bleeding on probing , matrix metalloproteinase , gastroenterology , biomarker , saliva , arthritis , periodontal disease , biochemistry , chemistry
Abstract Objective To investigate the impact of anti‐rheumatic medications on salivary matrix metalloproteinase (MMP)‐8 levels and MMP‐8/TIMP (tissue inhibitor of MMPs)‐1 ratio in patients with rheumatoid arthritis (RA) and periodontal findings during a 1‐year follow‐up. Materials and Methods Salivary MMP‐8 was measured by an immunofluorometric assay and TIMP‐1 by an enzyme‐linked immunosorbent assay of 53 patients with early untreated RA (ERA), naïve to synthetic disease modifying anti‐rheumatic drugs (DMARDs), of 28 patients with chronic RA (CRA), candidates for biologic DMARDs and of 43 age‐ and sex‐matched controls. Periodontal health was evaluated by bleeding on probing (BOP), pocket depth (PD), and periodontal inflammatory burden index (PIBI). Examinations were conducted twice for RA patients and once for controls. Results Salivary MMP‐8 level and MMP‐8/TIMP‐1 ratio associated positively with PIBI in patients with chronic RA (MMP‐8: p < 0.001 at baseline, p = 0.002 after follow‐up; MMP‐8/TIMP‐1 ratio p < 0.001, p = 0.003, respectively) and in controls (MMP‐8: p = 0.010, MMP‐8/TIMP‐1 ratio: p = 0.010). Salivary MMP‐8 levels were highest at the early stage of RA. The used DMARDs, synthetic or biologic, did not affect salivary MMP‐8 concentrations. Conclusions The use of synthetic or biologic DMARDs did not affect salivary MMP‐8 levels in RA patients regardless the duration of RA.