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Periodontal therapy and endothelial function in coronary artery disease: A randomized controlled trial
Author(s) -
Saffi Marco Aurélio L.,
RabeloSilva Eneida R.,
Polanczyk Carisi A.,
Furtado Mariana V.,
Montenegro Marlon M.,
Ribeiro Ingrid W. J.,
Kampits Cassio,
Rösing Cassiano K.,
Haas Alex N.
Publication year - 2018
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12909
Subject(s) - medicine , scaling and root planing , brachial artery , coronary artery disease , randomized controlled trial , periodontitis , chronic periodontitis , endothelial dysfunction , quadrant (abdomen) , gastroenterology , cardiology , clinical attachment loss , dentistry , surgery , blood pressure
Objective To assess the effects of periodontal treatment on endothelial function in patients with coronary artery disease. Materials and Methods A randomized controlled trial was conducted with 69 patients with stable coronary disease and severe periodontitis. The test group received nonsurgical periodontal therapy consisting of personalized oral hygiene instructions, subgingival scaling, and root planing per quadrant, whereas the control group received equal treatment after the study period. Endothelial function was assessed by measurement of brachial artery flow‐mediated dilation, concentrations of sVCAM ‐1, sICAM ‐1, and P‐selectin in serum before and 3 months after periodontal therapy. Results The test group exhibited statistically better periodontal parameters—plaque, probing depth, periodontal attachment loss, and bleeding on probing. No significant improvements were observed in the control (1.37%) and test (1.39%) groups in flow‐mediated dilation, with no significant between‐group difference. sVCAM ‐1 concentration increased in the control group (997.6 ± 384.4–1201.8 ± 412.5; p = 0.03), whereas in the test group, no significant changes were observed (915.1 ± 303.8–1050.3 ± 492.3; p = 0.17), resulting in a significant difference between the two groups ( p = 0.04). The same pattern was observed for concentrations of sICAM ‐1. Conclusion Periodontal treatment did not provide better vasodilation in patients with coronary disease in a short‐term follow‐up period, although it maintained blood concentrations of markers of vascular inflammation.