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A multicentre study of 268 cases of calcifying odontogenic cysts and a literature review
Author(s) -
de Arruda José Alcides A,
Schuch Lauren F,
Abreu Lucas G,
Silva Leni Verônica O,
Monteiro João Luiz GC,
Pinho Rodrigo FC,
Silva Leorik P,
Sousa Suzana COM,
Andrade Bruno Augusto B,
Romañach Mario José,
QC Lourenço Simone,
Batista Aline C,
Mendonça Elismauro Francisco,
Martins Manoela D,
Rados Pantelis V,
Rivero Elena RC,
Souza Lélia B,
Pinheiro Maria das GR,
Gomes Ana Paula N,
Vasconcelos Ana Carolina U,
Sobral Ana Paula V,
Mesquita Ricardo A
Publication year - 2018
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12906
Subject(s) - medicine , retrospective cohort study , odontogenic , oral and maxillofacial pathology , maxilla , lesion , biopsy , odontogenic cyst , dentistry , dermatology , pathology
Abstract Objectives To investigate the frequency of calcifying odontogenic cysts ( COC s) that have been submitted for microscopic examination from representative geographic regions of Brazil and to compare it with literature data. Materials and Methods A retrospective study was conducted on biopsies obtained from 1953 to 2016 at 10 Brazilian oral and maxillofacial pathology centres. A total of 198,350 biopsy specimens were analysed. Demographic data and histopathological diagnosis were evaluated descriptively and statistically. In addition, a literature review of case series was carried out in four electronic databases. Results A total of 268 cases of COC were surveyed, representing 0.1% of the oral lesions at the centres studied. Female patients in their second decade of life and the maxilla were more affected. The mean lesion size of symptomatic individuals was larger than that of cases without symptoms ( p  =   0.026). The literature review showed a higher frequency in Asia and Europe, mainly affecting men in the third decade of life. Conclusions COC is a rare lesion. Novel data on the clinicopathological features of 268 cases have been added to the literature. Data regarding gender and age of the Brazilian patients reported herein contrast with findings of case series and retrospective studies reported elsewhere.

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