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Detection of distant metastasis and prognostic prediction of recurrent salivary gland carcinomas using 18 F‐FDG PET/CT
Author(s) -
Lee Sang Hun,
Roh JongLyel,
Kim Jae Seung,
Lee Jeong Hyun,
Choi SeungHo,
Nam Soon Yuhl,
Kim Sang Yoon
Publication year - 2018
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12877
Subject(s) - medicine , mcnemar's test , distant metastasis , nuclear medicine , radiology , metastasis , proportional hazards model , carcinoma , pet ct , positron emission tomography , cancer , statistics , mathematics
Objective To compare the diagnostic accuracy of 18 F‐ FDG PET / CT and conventional contrast‐enhanced CT for the re‐staging of recurrent salivary gland carcinoma ( SGC ). Materials and Methods This study included 58 consecutive patients who underwent recurrent SGC s after definitive treatment. The recurrences were evaluated by 18 F‐ FDG PET / CT and contrast‐enhanced CT of the neck and chest. McNemar's test was used to compare the diagnostic accuracy of 18 F‐ FDG PET / CT with standard neck and chest CT imaging, and a Cox proportional hazards model was used to assess the prognostic value of PET / CT . Results Of 58 patients with recurrent SGC s, 17 (29%) had a local recurrence, 17 (29%) had a regional recurrence, and 38 (66%) had a distant metastasis, with these classifications showing overlap. The sensitivity and accuracy of 18 F‐ FDG PET / CT for the detection of distant metastases were significantly higher than those of CT ( p < 0.05), whereas, for detection of loco‐regional recurrences, they did not differ ( p > 0.1). The 18 F‐ FDG PET / CT ‐positive findings at distant sites were predictors of poor progression‐free and overall survival outcome (all p < 0.05). Conclusions 18 F‐ FDG PET / CT is a more effective method than CT for detecting distant site recurrences of SGC . This may lead to prognostic prediction for recurrent SGC s.