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Role of non‐coding RNA s in head and neck squamous cell carcinoma: A narrative review
Author(s) -
Sannigrahi MK,
Sharma R,
Panda NK,
Khullar M
Publication year - 2018
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12782
Subject(s) - rna , carcinogenesis , cancer research , microrna , head and neck squamous cell carcinoma , non coding rna , biology , antisense rna , long non coding rna , gene , cancer , head and neck cancer , genetics
Head and neck squamous cell carcinoma ( HNSCC ) is the sixth most common cancer worldwide with high recurrence, metastasis, and poor treatment outcome. Recent studies have reported that non‐coding RNA (nc RNA ) might play critical role in regulating different types of cancer. Micro RNA s (miRs) are short nc RNA s (20–25 nucleotides) responsible for post‐transcriptional regulation of gene expression and may have a role in oncogenesis by acting as oncomiRs or tumor suppressor miRs. Long non‐coding RNA s (lnc RNA s) are heterogenous group of nc RNA s more than 200 nucleotides long, can act in cis and/or in trans , and have been also implicated in carcinogenesis. These molecules have been suggested to be promising candidates as diagnostic and prognostic biomarkers and for development of novel therapeutic approaches. In this review, we have summarized recent findings on role of these nc RNA s in HPV ‐negative ( HPV −ve) and HPV ‐positive ( HPV +ve) HNSCC . The available literature supports differential expression of both micro RNA s and long non‐coding RNA s, which include oncogenic nc RNA s (miR‐21, miR‐31, miR‐155, miR‐211, HOTAIR , and MALAT 1) and tumor suppressor nc RNA s (let7d, miR‐17, miR‐375, miR‐139, and MEG 3) in HPV +ve HNSCC tumors as compared to HPV −ve tumors and they have distinct role in the pathophysiology of these two types of HNSCC s.