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Immunomodulatory effect of vitamin K2: Implications for bone health
Author(s) -
Myneni VD,
Mezey E
Publication year - 2018
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12759
Subject(s) - peripheral blood mononuclear cell , osteoporosis , vitamin d and neurology , medicine , vitamin , endocrinology , flow cytometry , postmenopausal osteoporosis , concanavalin a , t cell , cell growth , immunology , chemistry , bone mineral , immune system , biochemistry , in vitro
Objective In women with postmenopausal osteoporosis, vitamin K2 appears to decrease the incidence of hip, vertebral, and non‐vertebral fractures. Women with postmenopausal osteoporosis have more circulating activated T cells compared with healthy postmenopausal and premenopausal women, but the effects of vitamin K2 on T cells have not been studied. In this study, we have looked at T‐cell suppression by vitamin K2. Materials and methods Peripheral blood mononuclear cells ( PBMC s) from three healthy donors were used. The PBMC s were stimulated with the mitogens phytohemagglutinin and concanavalin A, and T‐cell proliferation was analyzed using flow cytometry based on carboxyfluorescein succinimidyl ester ( CSFE ) dye dilution. Results Vitamin K2 (60 and 100 μM) inhibited T‐cell proliferation. Vitamin K1 at the same concentrations did not inhibit T‐cell proliferation. Conclusion Vitamin K2 has immunomodulatory activities.