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Co‐inhibitory immune checkpoints in head and neck squamous cell carcinoma
Author(s) -
Deng WW,
Wu L,
Sun ZJ
Publication year - 2018
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12746
Subject(s) - immunosurveillance , immune system , inhibitory postsynaptic potential , head and neck squamous cell carcinoma , immune checkpoint , immunotherapy , downregulation and upregulation , cancer research , cancer , immunology , head and neck cancer , biology , medicine , neuroscience , gene , biochemistry
The upregulation of co‐inhibitory immune checkpoints hampers the immune response toward tumor cells and facilitates the tumor cells ability to evade immunosurveillance. Specific inhibitory immune checkpoint delivers inhibitory signals to T cells using multiple mechanisms. More in‐depth understanding of the co‐inhibitory immune checkpoints could be exploited for head and neck squamous cell carcinoma ( HNSCC ) treatment. In this review, we summarize the expression and the mechanism of partial co‐inhibitory immune checkpoint signals and discuss targeting co‐inhibitory immune checkpoints as an immunotherapeutic target for cancer therapy. This review may provide a better understanding of the co‐inhibitory immune checkpoints and could promote applications of immunotherapy.