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Association of sickle cell haemoglobinopathies with dental and jaw bone abnormalities
Author(s) -
Souza SFC,
Carvalho HLCC,
Costa CPS,
Thomaz EBAF
Publication year - 2018
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12742
Subject(s) - medicine , dentistry , mandible (arthropod mouthpart) , bone resorption , sickle cell trait , cancellous bone , pulp (tooth) , anatomy , biology , pathology , botany , disease , genus
Objective To estimate the association between sickle cell anaemia and trait with dental and jaw bone abnormalities. Subjects and Methods Subjects ( n = 369) were allocated to three groups: sickle cell anaemia, trait and control. Dental shape, number, size and position and changes in pulp chamber, root and periapex were analysed by intra‐oral periapical radiographs. Integrity of lamina dura, quality of cancellous bone and bone trabeculation were also evaluated. Prevalence ratios ( PR ) were calculated (α = 0.05). Results Sickle cell anaemia had higher prevalence ( PR :8.31) and number of teeth ( PR :13.40) with external resorption; higher number of teeth with pulp calcification; partial and total loss of lamina dura; and higher prevalence of changes in trabecular structure of maxilla ( PR :6.45) and mandible ( PR :5.34). Sickle cell trait showed higher prevalence ( PR :1.26) and higher number of teeth ( PR :1.98) with partial loss of lamina dura; higher number of teeth with hypercementosis, changes in shape, size, periapex, total loss of lamina dura; and higher prevalence of changes in mandibular trabecular bone ( PR :1.43). Conclusion Pulp calcification and external resorption of the root were the most frequent dental alterations in sickle cell anaemia group, while in trait was higher frequency of changes in shape, size, periapex and root. Jaw bone changes were most prevalent in both homozygous and heterozygous subjects.