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Oral epithelial MUC 1 and oral health
Author(s) -
Kho HS
Publication year - 2018
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12713
Subject(s) - oral health , medicine , dentistry
Objectives To provide information about MUC 1, epithelial membrane‐bound mucin, in terms of its role in oral health. Design The expression and functional roles of MUC 1 in the oral mucosa and salivary glands were reviewed. Information on the modulation of oral mucosal epithelial MUC 1 expression compared with that of endometrial epithelial MUC 1 expression was also reviewed. In addition, the possible associations between oral mucosal epithelial MUC 1 and oral diseases were explored. Results MUC 1 is expressed in the oral mucosa and major and minor salivary glands. Protection of oral mucosal surfaces is believed to be the main function of oral mucosal epithelial MUC 1. Its role in the salivary glands is thought to facilitate salivary flow through the ductal system. Information on the role of MUC 1 in signal transduction and modulation of immune function in the oral cavity is sparse. However, the possible roles of MUC 1 in dry mouth conditions, burning mouth syndrome, dental caries, and oral candidiasis have been suggested. Conclusions Despite limited information, it is clear that oral epithelial MUC 1 plays an important role in oral health. Further research evaluating the physiological and pathological roles of MUC 1 in the oral cavity is warranted.