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Determination of role of ceruloplasmin in oral potentially malignant disorders and oral malignancy—A cross‐sectional study
Author(s) -
Shah P H,
Venkatesh R,
More C B
Publication year - 2017
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12690
Subject(s) - oral submucous fibrosis , ceruloplasmin , medicine , gastroenterology , malignancy , leukoplakia , oral lichen planus , cancer , recurrent aphthous stomatitis , oxidative stress , lipid peroxidation , stomatitis , pathology
Objectives In the process of carcinogenesis, lipid peroxidation and increased oxidative stress lead to changes in certain antioxidants. This study was aimed to assess and co‐relate serum levels of ceruloplasmin in oral premalignancies and oral cancer so as to gauge its possible association with the process of carcinogenesis and to determine its role as tumor marker. Material and Methods The study population comprised of 300 participants, equally divided into six study groups, that is, oral submucous fibrosis ( OSMF ), oral leukoplakia ( OL ), nicotina stomatitis ( NS ), oral malignancy ( OM ), controls (C), and healthy controls ( HC ); 5 ml of blood was collected from ante cubital vein from each participant. The serum was analyzed for ceruloplasmin levels using ERBA CHEM 5 PLUS semiautomated chemistry analyzer and diagnostic kit by turbidimetric immunoassay. Results There were total 242 males and 58 females, who were between 18 and 82 years of age, with a mean of 45.31 ± 13.97 years. The serum ceruloplasmin levels were significantly increased in OM , OSMF , OL , and NS groups as compared to C and HC groups ( p < .001). No statistically significant difference was found in intragroup analysis of the disease groups ( p > .05). Conclusion Serum ceruloplasmin can be used as diagnostic marker for oral premalignant and malignant lesions.