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Gingival crevicular fluid levels of monocyte chemoattractant protein‐1 in patients with aggressive periodontitis
Author(s) -
Gunpinar S,
Alptekin NO,
Dundar N
Publication year - 2017
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12658
Subject(s) - aggressive periodontitis , medicine , monocyte , gastroenterology , pathogenesis , periodontitis , immunology
Objectives The purpose of this study was to investigate the gingival crevicular fluid ( GCF ) levels of monocyte chemoattractant protein ( MCP )‐1 in aggressive periodontitis (AgP) and whether GCF MCP ‐1 levels differ among localized (L) AgP and generalized (G) AgP. Material and Methods A total of 160 subjects including 80 AgP and 80 age‐ and gender‐matched periodontally healthy (H) controls were recruited in this cross‐sectional study ( NCT 02927704) . GCF samples were collected from 160 patients including 50 LA gP, 30 GA gP, and 80 H. Volume of GCF was measured by Periotron 8000 ® , and enzyme‐linked immunosorbent assay was used to assess MCP ‐1 levels. Results Compared to H controls, all clinical parameters and total amounts (pg 30 s −1 ) of MCP ‐1 were significantly higher in subjects with LA gP and GA gP ( P < 0.05). Although concentrations of GCF MCP ‐1 did not differ between LA gP and GA gP ( P > 0.05), total amounts of MCP ‐1 were higher in GA gP than LA gP ( P < 0.05). Conclusion It can be concluded that the total amount of MCP ‐1 level in GCF may be a potential determinant in AgP subjects. Increased MCP ‐1 levels in line with the degree of periodontal destruction in GA gP patients reveal that MCP ‐1 can be used to understand the disease pathogenesis of LA gP and GA gP.