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Interventions for the management of oral lichen planus: a review of the conventional and novel therapies
Author(s) -
Gupta S,
Ghosh S,
Gupta S
Publication year - 2017
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12634
Subject(s) - oral lichen planus , medicine , randomized controlled trial , clinical trial , dermatology , calcineurin , medline , oral medicine , erythema , cochrane library , narrative review , intensive care medicine , surgery , transplantation , dentistry , political science , law
Objective This narrative review focuses on the rationale and role of conventional and newer therapies in the management of oral lichen planus ( OLP ) with emphasis on randomized controlled trials (RCTs) reported over two decades. Materials and Methods Literature search was conducted to identify RCT s for the management of OLP from 1 January 1995 to 31 December 2015; Medline and Cochrane databases complemented with manual search were used. Primary outcome as resolution of pain was evaluated with the analysis of clinical resolution of erythema and ulceration as secondary outcome. Results The search provided 260 abstracts, of which 70 full‐text articles were included. Majority of trials used topical steroids with very few trials on newer therapies. It was found that topical steroids are effective for symptomatic management of OLP with equal efficacy shown by topical calcineurin inhibitors and retinoids. However, the side effect of transient burning sensation with relapse was more with calcineurin inhibitors. Conclusion Although the newer therapies offer advantage over steroids for the management of OLP in recalcitrant cases, extensive lesions, and cases unresponsive to steroids, but sufficient clinical data on their use are still lacking. Hence, more RCT s with large sample size, adequate treatment duration, and long‐term follow‐up are required for clinical utility.