Premium
Fetuin‐A, serum amyloid A and tumor necrosis factor alpha levels in periodontal health and disease
Author(s) -
Türer ÇC,
Ballı U,
Güven B
Publication year - 2017
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12625
Subject(s) - medicine , fetuin , gingivitis , serum amyloid a , gastroenterology , chronic periodontitis , periodontitis , tumor necrosis factor alpha , periodontal disease , endocrinology , inflammation , glycoprotein , dentistry , biology , microbiology and biotechnology
Objectives This study is evaluating fetuin‐A, serum amyloid A ( SAA ) and tumor necrosis factor alpha ( TNF ‐ α ) levels in gingival crevicular fluid ( GCF ) and serum samples in periodontal health and disease. Material and Methods Sixty patients were divided into three groups: Group 1 periodontal health ( n = 20), Group 2 gingivitis ( n = 20) and Group 3 chronic periodontitis ( CP ) ( n = 20). GCF and serum samples were evaluated using enzyme‐linked immunosorbent assay kit. Results SAA and TNF ‐ α levels in GCF and serum were significantly higher in patients with gingivitis and CP compared with controls ( P < 0.016). Contrarily, fetuin‐A levels in GCF and serum were significantly higher in controls than in patients with gingivitis and CP ( P < 0.016). In CP group, a significant correlation was observed between GCF ‐ SAA amount and the number of sites with 4 ≤ PPD ≤ 5 mm ( P < 0.05). There was a significant correlation between GCF ‐fetuin‐A levels and the number of sites with PPD ≥ 6 mm ( P < 0.05). GCF ‐ TNF ‐ α was found to have a significant relationship with the number of sites with 4 ≤ PPD ≤ 5 mm and PPD ≥ 6 mm ( P < 0.05). Conclusions In conclusion, serum and total levels of SAA significantly increased, whereas fetuin‐A levels significantly decreased, with increasing severity of PD .