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Immunoprofile of the adenomatoid odontogenic tumor
Author(s) -
Reichart PA,
Philipsen HP,
Khongkhunthian P,
Sciubba JJ
Publication year - 2017
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12572
Subject(s) - adenomatoid odontogenic tumor , pathology , immunohistochemistry , ameloblastoma , adenomatoid tumor , podoplanin , biology , cancer research , medicine , anatomy , maxilla
This study was focused on the immunohistochemical profile of the adenomatoid odontogenic tumor. A Pub/Medline search revealed a number of immunohistochemical studies including cytokeratin profiles, extracellular matrix proteins, Integrins, ameloblast‐associated proteins resorption regulators ( RANK , RANKL ), p53, PCNA , MDM 2 protein, cyclin D1, Ki‐67, Bcl‐2 metallothionein, metalloproteinases, D56 hepatocyte growth factor, c‐met, DNA methyltransferase, podoplanin, TGF ‐ β I, Smad‐2/3, Smad‐I‐5/‐8, Smad 4, beta‐ catenin, calretinin, and clonality. Careful interpretation of the findings indicates that the adenomatoid odontogenic tumor may be more of a hamartomatous than neoplastic nature.