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Pharmacological targeting of histamine H 4 receptor in periodontal disease
Author(s) -
Prestifilippo JP,
FernándezSolari J,
Martinel Lamas DJ,
Rios CE,
Mohn C,
Perazzo JC,
Rivera ES,
Elverdin JC,
Medina VA
Publication year - 2016
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12467
Subject(s) - medicine , periodontitis , inflammation , bone resorption , histamine , endocrinology , pathology
Objective The objective of this study was to investigate whether histamine H 4 receptor (H 4 R) antagonists could prevent experimental periodontitis ( EP )‐induced histological, functional and inflammatory alterations in submandibular gland ( SMG ), periodontal bone and gingiva. Methods Bilateral EP was induced for 2 weeks in anaesthetized male rats. The effect of systemic and local administration of H 4 R antagonists ( JNJ 7777120, JNJ 10191584) on histopathology and functionality of SMG , bone loss and gingival inflammation was evaluated. Results The subcutaneous administration of JNJ 7777120 prevented periodontitis‐induced SMG histological injury, reducing vacuolization and apoptosis and additionally reversed the increased prostaglandin E2 (PGE2) levels in SMG while it partially reversed the methacholine‐induced salivation reduction produced by periodontitis. JNJ 7777120 attenuated bone loss and the increased PGE 2 levels and inflammatory infiltration in gingival tissue of rats with periodontitis. Finally, local administration of JNJ 7777120 and JNJ 10191584 was also beneficial for improving periodontal parameters. Conclusions H 4 receptor antagonists are able to ameliorate periodontitis‐induced injury on SMG , gingival tissue and bone structure, suggesting that pharmacological targeting of H 4 R could be an attractive strategy to improve periodontal health.