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Oral chronic GVHD outcomes and resource utilization: a subanalysis from the chronic GVHD consortium
Author(s) -
Yuan A,
Chai X,
Martins F,
Arai S,
Arora M,
Correa ME,
Pidala J,
Cutler CS,
Lee SJ,
Treister NS
Publication year - 2016
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12429
Subject(s) - oral immunotherapy , chronic disease , medicine , immunology , immunotherapy , immune system
Objectives This study evaluated the extent to which oral chronic graft‐ versus ‐host disease ( cGVHD ) consensus assessments are predictive of management across institutions with and without oral medicine ( OM ) centers, and whether ancillary care guidelines are followed within clinical practice. Methods Longitudinal oral cGVHD data were abstracted from the cGVHD Consortium, and additional mouth‐specific management data were analyzed across five transplant centers. Results Seventy‐nine patients with 656 visits were observed for a median of 7.1 months with one visit per follow‐up month. Ancillary therapies for oral cGVHD were prescribed for 67% of patients for a median of 0.46 months (per follow‐up month) at OM centers and 0.78 months at non‐ OM centers. Patients treated with ancillary therapy were more likely to have an National Institutes of Health ( NIH ) mouth score of ≥1 ( P  < 0.001, odds ratio: 5.1) and mouth pain ( P  = 0.01, odds ratio: 2.6). The odds ratios of receiving ancillary therapy from OM experts were higher than transplant physicians (53%; P  = 0.03). Conclusions Oral cGVHD consensus assessments corresponding with ancillary therapy use were mouth pain and NIH mouth score, with higher odds ratios of receiving therapy from OM experts. Ancillary care guidelines for oral cGVHD are reflected in academic clinical practice with respect to utilization of recommended prescriptions.

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