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PRDM 1 expression on the epithelial component but not on ectopic lymphoid tissues of Warthin tumour
Author(s) -
Wang Y,
Zhou J,
Zhang Y,
Wang L,
Liu Y,
Fan L,
Zhu J,
Xu X,
Huang G,
Li X,
Xun W
Publication year - 2015
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12294
Subject(s) - ectopic expression , lymphatic system , pathology , component (thermodynamics) , epithelium , biology , medicine , gene , genetics , physics , thermodynamics
Objective To determine the role of PRDM 1, a key molecule for modulating the immune cells, in Warthin tumour ( WT ) pathogenesis. Subjects and methods Forty paraffin‐embedded parotid tissues of patients (mean age: 62.08 ± 11.90) with WT were retrieved from the pathology archives of Qindu Hospital from January 2012 to December 2012. The PRDM 1 expression was investigated in a cohort of WT by immunohistochemistry. Results PRDM 1 was expressed only on the epithelial component but not on ectopic lymphoid tissue of the tumour. Statistically, PRDM 1 expression rates between WT glandular epithelial cells (40/40 cases) and the tumour‐adjacent tissues (0/9 cases), and WT germinal centres (0/34 cases) and tonsil tissues (10/10 cases) were significantly different ( P < 0.001), respectively. Conclusions The PRDM 1 expression appeared to play an essential role in WT pathogenesis. A better understanding of it might give options for revealing possible novel management strategies.