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Detection of human papillomavirus in the oral cavities of persons with F anconi anemia
Author(s) -
Winer RL,
Huang CE,
Cherne S,
Stern JE,
Butsch Kovacic MS,
Mehta PA,
Sauter SL,
Galloway DA,
Katzenellenbogen RA
Publication year - 2015
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12286
Subject(s) - medicine , human papillomavirus , anemia , population , hpv infection , genotype , polymerase chain reaction , cross sectional study , gastroenterology , cervical cancer , cancer , pathology , biology , gene , genetics , environmental health
Objective We conducted a cross‐sectional study to describe the prevalence and correlates of type‐specific human papillomavirus ( HPV ) DNA in the oral cavities of persons with F anconi anemia. Materials and Methods Oral swabs were collected from 67 participants with F anconi anemia and tested for 27 HPV genotypes using polymerase chain reaction‐based methods. Results Participants were a mean of 18.6 (standard deviation, 10.0) years of age (range 4–47 years). The prevalence of oral HPV infection was 7.5%, and the prevalence of high‐risk HPV infection was 6.0%. HPV type 16 was not detected in any samples. Prevalence was higher in adults than in children (13.3% vs 2.7% in those ≥18 vs <18 years of age). Among adults, prevalence was higher in males than in females (25.0% vs 9.1%, respectively). Conclusions Prevalence of oral HPV infection in persons with F anconi anemia was comparable to estimates from other studies in the general population. However, in contrast to previous studies, we did not identify HPV type 16 (the type found in most HPV ‐related head and neck cancers) in any participants.