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Immunomodulation regulates mesenchymal stem cell‐based bone regeneration
Author(s) -
Su Y,
Shi S,
Liu Y
Publication year - 2014
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12248
Subject(s) - mesenchymal stem cell , regeneration (biology) , regenerative medicine , stem cell , clinical uses of mesenchymal stem cells , immune system , medicine , biology , microbiology and biotechnology , bioinformatics , immunology , cellular differentiation , adult stem cell , biochemistry , gene
Mesenchymal stem cell ( MSC )‐based regenerative medicine represents a promising frontier for bone reconstruction. Significant efforts have been devoted to clarifying the capacities of MSC s to repair or reconstruct bone tissue. This review provides a concise summary of current knowledge pertaining to the possible mechanisms of MSC action in the regeneration of bone, with particular focus on the interplay between donor MSC s and host immune response in the process of new bone regeneration.