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Defining the genomic landscape of head and neck cancers through next‐generation sequencing
Author(s) -
Rizzo G,
Black M,
Mymryk JS,
Barrett JW,
Nichols AC
Publication year - 2015
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12246
Subject(s) - head and neck squamous cell carcinoma , head and neck cancer , dna sequencing , personalized medicine , genomics , biology , cancer , single cell sequencing , genomic sequencing , computational biology , precision medicine , bioinformatics , cancer research , medicine , mutation , exome sequencing , genome , genetics , gene
Next‐generation sequencing (NGS) has revolutionized the field of genomics and improved our understanding of cancer biology. Advances have been achieved by sequencing tumor DNA and using matched normal DNA to filter out germ line variants to identify cancer‐specific changes. The identification of high incidences of activating mutations in head and neck squamous cell carcinoma (HNSCC) amenable to drug targeting has been made, with clear distinctions between the mutational profile of HPV‐positive and HPV‐negative tumors. This wealth of new understanding undoubtedly ameliorates our understanding of HNSCC cancer biology and elucidates clear targets for drug targeting which will guide future personalized medicine.