Premium
Transepithelial ion transport across duct cells of the salivary gland
Author(s) -
Ohana E
Publication year - 2015
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12201
Subject(s) - secretion , cystic fibrosis , cystic fibrosis transmembrane conductance regulator , ion transporter , mucin , apical membrane , chemistry , microbiology and biotechnology , duct (anatomy) , epithelium , salivary gland , bicarbonate , epithelial sodium channel , electrolyte , sodium , mucus , biophysics , endocrinology , medicine , biology , membrane , biochemistry , anatomy , pathology , ecology , organic chemistry , electrode
Fluid and electrolyte secretions are vital for all epithelia and when aberrant lead to numerous pathophysiological conditions. Electrolyte transport across epithelia generates the osmotic force for fluid movement and is mediated by several membrane proteins expressed on both apical and basolateral poles of epithelial cells. Sodium and chloride are crucial for regulation of fluid secretion, thus regulating salivary volume. Bicarbonate ( HCO 3 − ), on the other hand, is the major pH buffer; hence, aberrant HCO 3 − secretion is a major factor in diseases such as cystic fibrosis ( CF ) causing altered mucin hydration and solubilization. Here, the structure–function mechanisms of the major membrane transporters involved in salivary duct electrolyte transport are reviewed focusing on transepithelial movement of C l − and HCO 3 − .