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Placebo effect in burning mouth syndrome: a systematic review
Author(s) -
KutenShorrer M,
Kelley JM,
Sonis ST,
Treister NS
Publication year - 2014
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12192
Subject(s) - burning mouth syndrome , placebo , medicine , dermatology , alternative medicine , pathology
Placebo controls play a critical role in the evaluation of any pharmacotherapy. This review surveys the placebo arm in 12 randomized controlled trials ( RCT s) investigating burning mouth syndrome ( BMS ) and documents a positive placebo response in 6 of them. On average, treatment with placebos produced a response that was 72% as large as the response to active drugs. The lack of homogeneity in the use of placebos adds to the difficulty in comparing results and aggregating data. Future RCT s investigating BMS would benefit from larger sample sizes, adequate follow‐up periods, and use of a standard placebo.