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Elevated serum I g E in recurrent aphthous stomatitis and associations with disease characteristics
Author(s) -
Almoznino G,
Zini A,
Mizrahi Y,
Aframian DJ
Publication year - 2014
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12131
Subject(s) - recurrent aphthous stomatitis , medicine , stomatitis , family history , serology , disease , antibody , immunology , gastroenterology
Objectives To characterize demographic, clinical and serological parameters in recurrent aphthous stomatitis ( RAS ) patients and analyse their association with serum immunoglobulin E ( I g E ) levels. Subjects and Methods Forty‐nine patients with RAS responded to a questionnaire that included demographic background, stress status, smoking habits, history and course of RAS episodes. They were also subjected to relevant laboratory tests, including determination of serum I g E levels. Results A familial history of RAS was reported by 47.9% of the patients, stress in the previous year by 51.1% and smoking by 18.4%. Non‐ C aucasian origin, familial history of RAS , stress and smoking were associated with increased severity of RAS episodes. Haematological deficiencies were observed in 18.7% of RAS patients. Average I g E levels were increased and were significantly associated with younger age, ≤12 years of schooling, female gender, RAS episode frequency of every 2 weeks, early onset of RAS episodes and elevated C reactive protein levels. Conclusion Immunoglobulin E levels may be considered as part of the RAS patient's work‐up. Further research is needed to identify biological mechanisms that account for the observed associations.