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Dendritic cells and their role in periodontal disease
Author(s) -
Wilensky A,
Segev H,
Mizraji G,
Shaul Y,
Capucha T,
Shacham M,
Hovav AH
Publication year - 2014
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12122
Subject(s) - dendritic cell , immunology , follicular dendritic cells , periodontitis , biology , immune system , oral mucosa , microbiology and biotechnology , t cell , antigen presenting cell , medicine , dentistry , anatomy
T cells, particularly CD 4 + T cells, play a central role in both progression and control of periodontal disease, whereas the contribution of the various CD 4 + T helper subsets to periodontal destruction remains controversial, the activation, and regulation of these cells is orchestrated by dendritic cells. As sentinels of the oral mucosa, dendritic cells encounter and capture oral microbes, then migrate to the lymph node where they regulate the differentiation of CD 4 + T cells. It is thus clear that dendritic cells are of major importance in the course of periodontitis, as they hold the immunological cues delivered by the pathogen and the surrounding environment, allowing them to induce destructive immunity. In recent years, advanced immunological techniques and new mouse models have facilitated in vivo studies that have provided new insights into the developmental and functional aspects of dendritic cells. This progress has also benefited the characterization of oral dendritic cells, as well as to their function in periodontitis. Here, we provide an overview of the various gingival dendritic cell subsets and their distribution, while focusing on their role in periodontal bone loss.