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Interleukin‐4 RA gene polymorphism is associated with oral mucous membrane pemphigoid
Author(s) -
Carrozzo M,
Dametto E,
Fasano ME,
Broccoletti R,
Carbone M,
Rendine S,
Amoroso A
Publication year - 2014
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12106
Subject(s) - genotype , single nucleotide polymorphism , odds ratio , immunology , allele , medicine , cytokine , gastroenterology , snp , microbiology and biotechnology , gene , biology , genetics
Objective The aim of this study was to analyse whether the polymorphisms of several pro‐ and anti‐inflammatory cytokines may influence the susceptibility to predominantly oral Mucous membrane pemphigoid ( MMP ) in a Northern Italian population. Material and Methods DNA was obtained from 41 MMP patients (29 with exclusively oral pemphigoid [ OP ]) and 140 unrelated bone marrow donors. Thirteen cytokine genes with 22 single‐nucleotide polymorphisms ( SNP ) were studied by a sequence‐specific PCR assay. Results There was no significant difference between the patients taken together and healthy controls for any cytokine gene polymorphism studied. However, the allele A of the IL ‐4 receptor A ( IL ‐4 RA ) was significantly more frequent in OP than controls ( P < 0.05), causing an increased frequency of genotype A/A in OP patients (89.7 vs 67.9, odds ratio: 4.11, 95% confidence intervals 1.18–14.28, P = 0.023, Pc = 0.046). Conclusion IL ‐4 RA ‐1902 A/A genotype has been associated with a reduced response to IL ‐4 and has been found in 90% OP patient. Giving the supposed importance of IL ‐4 in MMP fibrotic process, our results can partially explain the low likelihood of scarring in OP patients.