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Immunomodulatory properties of dental tissue‐derived mesenchymal stem cells
Author(s) -
Li Z,
Jiang CM,
An S,
Cheng Q,
Huang YF,
Wang YT,
Gou YC,
Xiao L,
Yu WJ,
Wang J
Publication year - 2014
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12086
Subject(s) - mesenchymal stem cell , immune system , periodontal ligament stem cells , immunology , clinical uses of mesenchymal stem cells , multipotent stem cell , inflammation , bone marrow , stem cell , dental follicle , biology , periodontitis , microbiology and biotechnology , cancer research , medicine , adult stem cell , in vitro , progenitor cell , endothelial stem cell , dentistry , alkaline phosphatase , biochemistry , enzyme
In addition to their well‐established self‐renewal and multipotent differentiation properties, mesenchymal stem cells ( MSC s) also possess potent immunomodulatory functions both in vitro and in vivo , which render them a potential novel immunotherapeutic tool for a variety of autoimmune and inflammation‐related diseases. The major mechanisms may involve (1) the secretion of an array of soluble factors such as prostaglandin E 2 ( PGE 2 ), indoleamine 2, 3‐dioxygenase ( IDO ), transforming growth factor‐β ( TGF ‐β), and human leukocyte antigen G 5 ( HLA ‐ G 5); (2) interactions between MSC s and immune cells such as T cells, B cells, macrophages, and dendritic cells. Recently, increasing evidence has supported that MSC s derived from dental tissues are promising alternative sources of multipotent MSC s. We here provide a thorough and extensive review about new findings in the immunomodulatory functions of MSC s derived from several dental tissues, including dental pulp, periodontal ligament, gingiva, exfoliated deciduous teeth, apical papilla, and dental follicle, respectively. The immunomodulatory properties of dental MSC s place them as a more accessible cell source than bone marrow‐derived MSC s for cell‐based therapy of immune and inflammation‐related diseases.