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Evaluation of salivary biomarker profiles following non‐surgical management of chronic periodontitis
Author(s) -
Prakasam S,
Srinivasan M
Publication year - 2014
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12085
Subject(s) - biomarker , medicine , periodontitis , chronic periodontitis , saliva , pathology , dentistry , biology , biochemistry
Objectives Soluble toll‐like receptor‐2 ( sTLR ‐2) and cytokines in saliva were assessed as clinical markers for chronic periodontitis in a longitudinal study. Materials and Methods Unstimulated whole saliva was collected from 20 periodontally healthy individuals and 20 patients with chronic periodontitis at diagnosis and at 1 and 6 weeks following scaling and root planing ( SRP ). Biomarkers including the cytokines ( IL ‐4, IL ‐6, IL ‐10, and IL ‐17), sTLR ‐2, and sCD 14 in saliva were measured by enzyme‐linked immunosorbent assay. Mann–Whitney U ‐test and Student's t ‐test were used to determine the significance between healthy and chronic periodontitis groups and that between pre‐ and post‐ SRP samples, respectively. Results Salivary sTLR ‐2, IL ‐17, and IL ‐10 levels were significantly lower and those of sCD 14, IL ‐6, and IL ‐4 were significantly higher in patients with chronic periodontitis as compared with healthy controls. Furthermore, sTLR ‐2 and IL ‐4 in saliva reached levels comparable to those of healthy individuals at 6‐week re‐evaluation visit, implicating a correlation of the two markers with the disease process. Conclusions Our data suggest that salivary sTLR ‐2 is a potential prognostic or maintenance marker for chronic periodontitis. The observed variability of salivary cytokines is consistent with the role of these cytokines in the progression of chronic periodontitis.