Premium
Gene polymorphisms, tobacco exposure and oral cancer susceptibility: a study from G ujarat, W est I ndia
Author(s) -
Singh RD,
Haridas N,
Shah FD,
Patel JB,
Shukla SN,
Patel PS
Publication year - 2014
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12079
Subject(s) - genotype , cancer , medicine , gene , carcinogen , genetics , biology
Polymorphic variability in the enzymes involved in biotransformation of tobacco‐related pro‐carcinogens plays an important role in modulating oral cancer susceptibility. CYP 1A1*2 A , CYP 1A1*2 C , GSTM 1 and GSTT 1 polymorphisms were determined in 122 oral carcinoma cases and 127 controls from G ujarat, W est I ndia using PCR ‐based methods. The results revealed that the polymorphic variants of CYP 1A1 gene did not show association towards oral cancer risk. The GSTM 1 and GSTT 1 null genotypes were found to be over‐represented in patients than controls, suggesting a moderate increase in risk of oral cancer. The oral cancer risk was significantly increased in the patients having either alone or concurrent deletion of GSTM 1 and GSTT 1 . The results also suggested significant association between tobacco habits, especially chewing, variant genotypes of CYP 1 A 1 , GSTM 1 and GSTT 1 and oral cancer risk. Our data have provided evidence that GST polymorphism modified the susceptibility to oral cancer and individuals with variant genotypes of the three genes with tobacco habits are at significant risk of developing oral cancer.