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Low/negative expression of DDX 3 might predict poor prognosis in non‐smoker patients with oral cancer
Author(s) -
Lee CH,
Lin SH,
Yang SF,
Yang SM,
Chen MK,
Lee H,
Ko JL,
Chen CJ,
Yeh KT
Publication year - 2014
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12076
Subject(s) - medicine , cancer , cancer research , oncology
Objective DDX 3 has diverse biological functions in translation control, cell growth regulation, and tumor progression. Oral squamous cell carcinoma ( OSCC ) is a common malignant tumor worldwide with a poor clinical prognosis. The impact of DDX 3 expression in OSCC is seldom discussed. Materials and Methods Tumor tissues and adjacent normal tissues were obtained from 324 patients with OSCC . In this study, we used immunohistochemical staining methods to investigate the associations between DDX 3 expression and the clinicopathological characteristics of OSCC . Results Low/negative DDX 3 expression in tumor cells was significantly associated OSCC patient characteristics including male gender ( P < 0.001), smoking ( P < 0.001), alcohol consumption ( P < 0.001), betel quid chewing ( P = 0.002), poor relapse‐free survival ( P = 0.001), and poor overall survival (OS) ( P = 0.001). Patients with low/negative DDX 3 expression, and particularly non‐smoker OSCC patients, had significantly worse OS as defined by the log‐rank test ( P = 0.020 for all cases; P = 0.008 for non‐smoker patients). In non‐smoker patients with OSCC, low/negative DDX 3 expression in tumor cells was associated with poor prognosis ( P = 0.024) and a 3.802‐fold higher death risk, as determined by Cox regression. Conclusions Low/negative DDX 3 expression in tumor cells was significantly associated with aggressive clinical manifestations and might be an independent survival predictor, particularly in non‐smoker patients with OSCC.