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Evaluation of the expression of p53, MDM 2, and SUMO ‐1 in oral lichen planus
Author(s) -
Oliveira Alves MG,
Balducci I,
Rodarte Carvalho Y,
Cabral LAG,
Nunes FD,
Almeida JD
Publication year - 2013
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12068
Subject(s) - oral lichen planus , epithelial dysplasia , immunohistochemistry , carcinogenesis , dysplasia , pathology , h&e stain , mdm2 , hyperplasia , malignant transformation , carcinoma , biology , cancer research , basal cell , medicine , apoptosis , cancer , biochemistry , genetics
Objective The objective of this study was to compare the expression of proteins p53, MDM 2, and SUMO ‐1 in oral lichen planus ( OLP ) lesions, epithelial dysplasia, and squamous cell carcinoma. Materials and Methods The sample consisted of the following five groups of cheek mucosa lesions: normal mucosa ( NM ), inflammatory fibrous hyperplasia ( IFH ), lichen planus, epithelial dysplasia, and squamous cell carcinoma. The tissue samples were stained with hematoxylin‐eosin and submitted to immunohistochemistry using anti‐p53, anti‐ MDM 2, and anti‐ SUMO ‐1 antibodies. Results The results of this study demonstrated similar expression of p53 and MDM 2 between OLP , oral epithelial dysplasia and, to a lesser extent, between OLP and oral squamous cell carcinoma ( OSCC ). However, for SUMO ‐1 a similar expression was observed in OLP , NM , and IFH . Conclusions The results demonstrated overexpression of important proteins (p53 and MDM 2) related to regulatory mechanisms of apoptosis in OLP , suggesting that there is a favorable environment for malignant transformation. The expression of SUMO ‐1 in OLP was similar to NM and IFH , suggesting that alterations of this protein occur at later stages of carcinogenesis, because important overexpression occurred in oral epithelial dysplasia and OSCC .