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Growth hormone therapy and craniofacial bones: a comprehensive review
Author(s) -
Litsas G
Publication year - 2013
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12041
Subject(s) - craniofacial , endocrinology , somatic cell , bone remodeling , medicine , bone mass , linear growth , growth hormone , craniofacial abnormality , physiology , hormone , biology , osteoporosis , mathematics , psychiatry , gene , biochemistry
Growth hormone ( GH ) has significant effects on linear bone growth, bone mass and bone metabolism. The primary role of GH supplementation in children with GH deficiency, those born small for gestational age or with other types of disorders in somatic development is to increase linear growth. However, GH therapy seems to elicit varying responses in the craniofacial region. Whereas the effects of GH administration on somatic development are well documented, comparatively little is known of its effects on the craniofacial region. The purpose of this review was to search the literature and compile results from both animal and human studies related to the impact of GH on craniofacial growth.