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Significant reduction of homocysteine level with multiple B vitamins in atrophic glossitis patients
Author(s) -
Sun A,
Wang YP,
Lin HP,
Chen HM,
Cheng SJ,
Chiang CP
Publication year - 2013
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12035
Subject(s) - hematinic , glossitis , homocysteine , medicine , vitamin b12 , gastroenterology , vitamin , folic acid , concomitant , cobalamin , b vitamins , pathology , tongue
Objective This study evaluated whether supplementations of different vitamins and iron could reduce the serum homocysteine levels in 91 atrophic glossitis ( AG ) patients. Materials and Methods Atrophic glossitis ( AG ) patients with concomitant deficiencies of vitamin B 12 only ( n = 39, group I), folic acid only ( n = 10, group II ), iron only ( n = 9, group III ), or vitamin B 12 plus iron ( n = 19, group IV ) were treated with vitamin BC capsules plus deficient hematinics. AG patients without definite hematinic deficiencies ( n = 14, group V ) were treated with vitamin BC capsules only. The blood homocysteine and hematinic levels at baseline and after treatment till all oral symptoms had disappeared were measured and compared by paired t ‐test. Results Supplementations with vitamin BC capsules plus corresponding deficient hematinics for groups I , II , III , IV patients and with vitamin BC capsules only for group V patients could reduce the high serum homocysteine levels to significantly lower levels after a mean treatment period of 8.3–11.6 months (all P ‐values < 0.05). Conclusion Supplementations with vitamin BC capsules plus corresponding deficient hematinics or with vitamin BC capsules only can reduce the high serum homocysteine levels to significantly lower levels in AG patients.