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Carbon nanotubes functionalized with sodium hyaluronate restore bone repair in diabetic rat sockets
Author(s) -
Sá MA,
Andrade VB,
Mendes RM,
Caliari MV,
Ladeira LO,
Silva EE,
Silva GAB,
CorrêaJúnior JD,
Ferreira AJ
Publication year - 2013
Publication title -
oral diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.953
H-Index - 87
eISSN - 1601-0825
pISSN - 1354-523X
DOI - 10.1111/odi.12030
Subject(s) - diabetes mellitus , streptozotocin , bone healing , sodium hyaluronate , dentistry , medicine , chemistry , urology , endocrinology , surgery
Objective We evaluated the effects of sodium hyaluronate ( HY ) and carbon nanotubes functionalized with HY ( HY ‐ CNT ) on bone repair in the tooth sockets of diabetic rats. Materials and Methods Diabetes was induced by streptozotocin (50 mg kg −1 i.v.), and the sockets were divided into normal control, diabetic control, diabetic treated with HY (1%), and diabetic treated with HY‐CNT (100 μg ml −1 ) groups. The sockets were analyzed according to the percentage of bone formation and the number of cell nuclei. Results The percentage of bone trabeculae was lower in diabetic control animals (11.16 ± 5.10% vs 41.92 ± 6.34% in normal animals) after 14 days. Treating diabetic animals with HY or HY ‐ CNT significantly increased the percentage of neoformed trabeculae ( HY : 29.43 ± 3.29%; HY ‐ CNT : 36.90 ± 3.07%). Moreover, the sockets of diabetic animals had an increased number of cell nuclei and HY or HY ‐ CNT reduced this parameter. Conclusion Our results indicate that HY and HY ‐ CNT restore bone repair in the tooth sockets of diabetic rats, suggesting that these biomaterials are potential adjuvant therapies for the management of diabetes.