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Microtomographic analysis of the effect of sodium alendronate on orthodontic movement in rats
Author(s) -
Lopes Luiza Lassi de Araújo,
Barros Silva Paulo Goberlânio,
Damasceno Juliana Ximenes,
Martins Joyce Ohana de Lima,
Silva Karla Rovaris,
Sousa Frederico Barbosa,
Dantas Hugo Victor,
Ribeiro Thyciana Rodrigues,
Alencar Phillipe Nogueira Barbosa
Publication year - 2021
Publication title -
orthodontics and craniofacial research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 55
eISSN - 1601-6343
pISSN - 1601-6335
DOI - 10.1111/ocr.12410
Subject(s) - molar , medicine , saline , dentistry , analysis of variance , orthodontics , sodium , urology , chemistry , organic chemistry
Objective To evaluate the effect of sodium alendronate on orthodontic tooth movement in rats using microtomographic analysis. Settings and sample population Thirty male Wistar rats ( Rattus norvegicus ) were divided into three groups of 10 rats and administered saline (control), 1 mg/kg sodium alendronate or 6 mg/kg sodium alendronate, respectively. Materials and Methods The drug was administered once per week for 5 weeks by gavage. Orthodontic movement was induced during the last 2 weeks of medication administration by inserting a closed nickel‐titanium spring between the left upper first molar and central incisors. The opposite side served as the control. Tooth movement and bone trabeculation in the furcation region were evaluated by microtomographic analysis in the first (moved) and third (static) molars. The data were subjected to one‐way or two‐way ANOVA and Bonferroni test ( P < .05). Results The microtomographic images of the group that received 6 mg/kg sodium alendronate demonstrated significantly less tooth movement ( P = .048), less space between the trabeculae ( P = .031) and greater number of bone trabeculae ( P = .033) compared to the other groups. There were no statistically significant differences in bone volume and mean trabecular thickness between the three groups. The static teeth did not show the same alterations ( P > .05). Conclusion Sodium alendronate treatment reduced tooth movement in rats.