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Personalized scaffolding technologies for alveolar bone regenerative medicine
Author(s) -
Yu Ning,
Nguyen Trang,
Cho Young D.,
Kavanagh Nolan M.,
Ghassib Iya,
Giannobile William V.
Publication year - 2019
Publication title -
orthodontics and craniofacial research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 55
eISSN - 1601-6343
pISSN - 1601-6335
DOI - 10.1111/ocr.12275
Subject(s) - scaffold , dental alveolus , regenerative medicine , medicine , regeneration (biology) , dentistry , biomedical engineering , stem cell , biology , genetics , microbiology and biotechnology
Structured Abstract The reconstruction of alveolar bone defects associated with teeth and dental implants remains a clinical challenge in the treatment of patients affected by disease or injury of the alveolus. The aim of this review was to provide an overview on advances made in the use of personalized scaffolding technologies coupled with biologics, cells and gene therapies that offer future clinical applications for the treatment of patients requiring periodontal and alveolar bone regeneration. Over the past decade, advancements in three‐dimensional (3D) imaging acquisition technologies such as cone‐beam computed tomography (CBCT) and precise scaffold fabrication methods such as 3D bioprinting have resulted in personalized scaffolding constructs based on individual patient‐specific anatomical data. Furthermore, ‘fiber‐guiding’ scaffold designs utilize topographical cues to guide ligamentous fibers to form in orientation towards the root surface to improve tooth support. Therefore, a topic‐focused literature search was conducted looking into fiber‐guiding and image‐based scaffolds and their associated clinical applications.