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Effect of exogenous retinoic acid on tooth movement and periodontium healing following tooth extraction in a rat model
Author(s) -
Nishio C.,
Rompré P.,
Moldovan F.
Publication year - 2017
Publication title -
orthodontics and craniofacial research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.664
H-Index - 55
eISSN - 1601-6343
pISSN - 1601-6335
DOI - 10.1111/ocr.12151
Subject(s) - dental alveolus , medicine , periodontium , isotretinoin , molar , dentistry , bone healing , anatomy , dermatology , acne
Structured Abstract Objectives To evaluate the effect of isotretinoin on orthodontic tooth movement ( OTM ) and wound healing following exodontia. Setting and Sample Population Sixteen 40‐day‐old male Wistar rats were divided into two groups: (a) OTM and (b) tooth extraction ( TE ) of the upper 1st molar and OTM . The experimental animals were treated with isotretinoin (7.5 mg/kg) and the control animals with oil solution for 37 days. Materials and methods The OTM and bone volume were evaluated by the micro‐ CT and the periodontium healing was assessed by immunohistochemistry for VEGF ‐C, COX ‐2 and IL ‐1ß. Results The animals of both groups submitted to the TE showed a statistically significant decrease in the bone volume percentage and increase in OTM . No significant difference of OTM and bone volume was observed between the control and experimental group. However, the alveolar bone of the isotretinoin group revealed more medullary spaces with inflammatory, hematopoietic cells, blood vessels and intense immunolabeling for VEGF ‐C. This group also showed faster gingival regeneration. No significant difference was observed in the COX ‐2 and IL ‐1ß labelings following TE between both groups. Conclusion The isotretinoin did not affect the OTM nor did it cause an alteration in maxillary bone volume. This exogenous acid may contribute to the acceleration of gingival healing.