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Obesity is a risk factor for developing critical condition in COVID‐19 patients: A systematic review and meta‐analysis
Author(s) -
Földi Mária,
Farkas Nelli,
Kiss Szabolcs,
Zádori Noémi,
Váncsa Szilárd,
Szakó Lajos,
Dembrovszky Fanni,
Solymár Margit,
Bartalis Eszter,
Szakács Zsolt,
Hartmann Petra,
Pár Gabriella,
Erőss Bálint,
Molnár Zsolt,
Hegyi Péter,
Szentesi Andrea
Publication year - 2020
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1111/obr.13095
Subject(s) - medicine , intensive care unit , odds ratio , meta analysis , body mass index , confidence interval , obesity , risk factor , intensive care , mechanical ventilation , cohort study , retrospective cohort study , intensive care medicine
Summary The disease course of COVID‐19 varies from asymptomatic infection to critical condition leading to mortality. Identification of prognostic factors is important for prevention and early treatment. We aimed to examine whether obesity is a risk factor for the critical condition in COVID‐19 patients by performing a meta‐analysis. The review protocol was registered onto PROSPERO (CRD42020185980). A systematic search was performed in five scientific databases between 1 January and 11 May 2020. After selection, 24 retrospective cohort studies were included in the qualitative and quantitative analyses. We calculated pooled odds ratios (OR) with 95% confidence intervals (CIs) in meta‐analysis. Obesity was a significant risk factor for intensive care unit (ICU) admission in a homogenous dataset (OR = 1.21, CI: 1.002‐1.46; I2 = 0.0%) as well as for invasive mechanical ventilation (IMV) (OR = 2.05, CI: 1.16‐3.64; I2 = 34.86%) in COVID‐19. Comparing body mass index (BMI) classes with each other, we found that a higher BMI always carries a higher risk. Obesity may serve as a clinical predictor for adverse outcomes; therefore, the inclusion of BMI in prognostic scores and improvement of guidelines for the intensive care of patients with elevated BMI are highly recommended.