Premium
Emerging role of m 6 A RNA methylation in nutritional physiology and metabolism
Author(s) -
Wu Jiamin,
Frazier Katya,
Zhang Jingfei,
Gan Zhending,
Wang Tian,
Zhong Xiang
Publication year - 2020
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1111/obr.12942
Subject(s) - crosstalk , methylation , dna methylation , biology , gene expression , rna , physiology , rna methylation , epigenetics , gene , regulation of gene expression , metabolism , bioinformatics , genetics , endocrinology , methyltransferase , physics , optics
Summary N 6 ‐methyladenine (m 6 A) is the most prevalent type of internal RNA methylation in eukaryotic mRNA and plays critical roles in regulating gene expression for fundamental cellular processes and diverse physiological functions. Recent evidence indicates that m 6 A methylation regulates physiology and metabolism, and m 6 A has been increasingly implicated in a variety of human diseases, including obesity, diabetes, metabolic syndrome and cancer. Conversely, nutrition and diet can modulate or reverse m 6 A methylation patterns on gene expression. In this review, we summarize the recent progress in the study of the m 6 A methylation mechanisms and highlight the crosstalk between m 6 A modification, nutritional physiology and metabolism.