Premium
Impact of bariatric surgery on serum uric acid levels and the incidence of gout—A meta‐analysis
Author(s) -
Yeo Charleen,
Kaushal Sanghvi,
Lim Beatrice,
Syn Nicholas,
Oo Aung Myint,
Rao Jaideepraj,
Koura Aaryan,
Yeo Danson
Publication year - 2019
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1111/obr.12940
Subject(s) - medicine , gout , incidence (geometry) , uric acid , body mass index , obesity , surgery , meta analysis , weight loss , subgroup analysis , hyperuricemia , physics , optics
Summary Gout is characterized by high serum uric acid (SUA) levels and arthritis. It is associated with obesity and metabolic syndrome. Bariatric surgery has been associated with decreased SUA levels and overall gout incidence. This meta‐analysis aims to summarize the current evidence on bariatric surgery, gout and SUA levels. A literature review was performed on papers published from 2000 up till December 2018. Original studies investigating the impact of bariatric surgery on SUA levels or gout incidence were evaluated. Twenty studies with a total of 5,233 patients were analysed. Majority (n=14) had a follow‐up duration of at least 12 months. The mean preoperative body mass index (BMI) was 45.2kg m −2 . The mean preoperative SUA level was 6.5mg dL −1 . Subgroup analysis demonstrated a mean decrease in SUA levels (−0.73mg dL −1 ) from the third postoperative month onwards, which was sustained until the third postoperative year (−1.91mg dL −1 ). There was a rise in SUA levels in the first post‐operative month. Meta‐regression analyses demonstrated a proportionate linear relationship between the change in BMI and SUA levels. Post‐bariatric surgery weight loss is associated with reduced SUA levels and decreased incidence of gout attacks. However, this is only evident from the third post‐operative month onwards.