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Microbiome‐based mechanisms hypothesized to initiate obesity‐associated rheumatoid arthritis
Author(s) -
Luo Y.,
Blackledge W. C.
Publication year - 2018
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1111/obr.12671
Subject(s) - microbiome , rheumatoid arthritis , adipokine , medicine , obesity , immunology , pathogenesis , epidemiology , bioinformatics , biology , insulin resistance
Summary Worldwide, the growing obesity pandemic contributes to a range of chronic diseases. Recent epidemiological studies have suggested an association between obesity and the development of rheumatoid arthritis (RA), particularly among young women, whereby pro‐inflammatory effects of adipokines provide one explanatory hypothesis. Yet, recent clinical and laboratory‐based studies provide emerging evidence indicating microbiome involvement in RA initiation and development, including anti‐citrullinated antibody formation and Th17 cell activation. Obesity and RA‐associated microbiome alteration might provide a plausible link to address the impact of obesity to RA pathogenesis. The microbiome's influence on RA development – at mucosal as well as articular sites – and relevant pathophysiological mechanisms regarding obesity's association with RA are presented herein to discuss this hypothesis and aid understanding of obesity's role in RA development.