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Ghrelin function in human obesity and type 2 diabetes: a concise review
Author(s) -
Churm R,
Davies JS,
Stephens JW,
Prior SL
Publication year - 2017
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1111/obr.12474
Subject(s) - ghrelin , energy homeostasis , type 2 diabetes , endocrinology , glucose homeostasis , medicine , lipid metabolism , homeostasis , diabetes mellitus , hormone , obesity , hypothalamus , insulin resistance , biology
Summary The 28 amino acid hormone, ghrelin, has been found to have various effects on metabolism. This review will focus on the pathways integrated into ghrelin's effect within the hypothalamus, pancreas and adipocytes. The identification of molecules and pathways that regulate ghrelin‐mediated lipid retention could establish new mechanisms underlying cellular energy homeostasis. The impact of acyl‐ghrelin on glucose metabolism and lipid homeostasis may allow for novel preventative or early intervention therapeutic strategies to treat obesity related type 2 diabetes and associated metabolic dysfunction.