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Is there a relationship between obesity and tooth loss and edentulism? A systematic review and meta‐analysis
Author(s) -
Nascimento G. G.,
Leite F. R. M.,
Conceição D. A.,
Ferrúa C. P.,
Singh A.,
Demarco F. F.
Publication year - 2016
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1111/obr.12418
Subject(s) - edentulism , tooth loss , medicine , meta analysis , obesity , odds ratio , odds , observational study , dentistry , logistic regression , weight loss , confounding , oral health
Summary This study conducted a systematic review to assess the bi‐directional association between tooth loss/edentulism and obesity. Electronic searches were performed in four different databases. Observational studies that tested associations between tooth loss/edentulism and obesity as either exposures or outcomes were included. Additionally, meta‐analyses, funnel plots and sensitivity analyses were conducted to synthesize the evidence. A total of 549 articles were identified in the electronic database search. Out of which, 16 studies were included within the meta‐analyses: 75% considered tooth loss/edentulism as exposure and obesity as outcome, whereas 25% alternatively considered obesity as exposure and tooth loss/edentulism as outcome. Pooled estimates showed that obese individuals had 1.49 (95%CI 1.20–1.86) and 1.25 (95%CI 1.10–1.42) times higher odds of having any tooth loss and edentulism, respectively. Alternatively, when tooth loss or edentulism were considered as exposures, individuals with any tooth loss had 1.41 (95%CI 1.11–1.79) times higher odds for obesity, while edentates had even higher odds (OR 1.60; 95%CI 1.29–2.00). The results indicate a bi‐directional association between tooth loss and obesity. Considering that all selected studies were of cross‐sectional study design limiting inferences on temporality, longitudinal prospective studies are required to test the causal relationship between tooth loss/edentulism and obesity or vice a versa. © 2016 World Obesity