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Monocarboxylate transporters: new players in body weight regulation
Author(s) -
Carneiro L.,
Pellerin L.
Publication year - 2015
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1111/obr.12256
Subject(s) - context (archaeology) , phenotype , energy homeostasis , biology , transporter , obesity , homeostasis , body weight , gene , microbiology and biotechnology , genetics , endocrinology , paleontology
Summary Over the last two decades, several genes have been identified that appear to play a role in the regulation of energy homeostasis and body weight. For a small subset of them, a reduction or an absence of expression confers a resistance to the development of obesity. Recently, a knockin mouse for a member of the monocarboxylate transporter ( MCT ) family, MCT 1, was demonstrated to exhibit a typical phenotype of resistance to diet‐induced obesity and a protection from its associated metabolic perturbations. Such findings point out at MCTs as putatively new therapeutic targets in the context of obesity. Here, we will review what is known about MCTs and their possible metabolic roles in different organs and tissues. Based on the description of the phenotype of the MCT 1 knockin mouse, we will also provide some insights about their putative roles in weight gain regulation.