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Meta‐analysis on night shift work and risk of metabolic syndrome
Author(s) -
Wang F.,
Zhang L.,
Zhang Y.,
Zhang B.,
He Y.,
Xie S.,
Li M.,
Miao X.,
Chan E. Y. Y.,
Tang J. L.,
Wong M. C. S.,
Li Z.,
Yu I. T. S.,
Tse L. A.
Publication year - 2014
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1111/obr.12194
Subject(s) - meta analysis , relative risk , confidence interval , medicine , shift work , metabolic syndrome , observational study , random effects model , pooled analysis , publication bias , demography , obesity , psychiatry , sociology
Summary This study aims to quantitatively summarize the association between night shift work and the risk of metabolic syndrome ( MetS ), with special reference to the dose–response relationship with years of night shift work. We systematically searched all observational studies published in E nglish on P ub M ed and E mbase from 1971 to 2013. We extracted effect measures (relative risk, RR ; or odd ratio, OR ) with 95% confidence interval ( CI ) from individual studies to generate pooled results using meta‐analysis approach. Pooled RR was calculated using random‐ or fixed‐effect model. D owns and B lack scale was applied to assess the methodological quality of included studies. A total of 13 studies were included. The pooled RR for the association between ‘ever exposed to night shift work’ and MetS risk was 1.57 (95% CI = 1.24–1.98, p heterogeneity = 0.001), while a higher risk was indicated in workers with longer exposure to night shifts ( RR = 1.77, 95% CI = 1.32–2.36, p heterogeneity = 0.936). Further stratification analysis demonstrated a higher pooled effect of 1.84 (95% CI = 1.45–2.34) for studies using the NCEP ‐ ATPIII criteria, among female workers ( RR = 1.61, 95% CI = 1.10–2.34) and the countries other than A sia ( RR = 1.65, 95% CI = 1.39–1.95). Sensitivity analysis confirmed the robustness of the results. No evidence of publication bias was detected. The present meta‐analysis suggested that night shift work is significantly associated with the risk of MetS , and a positive dose–response relationship with duration of exposure was indicated.