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Brown adipose tissue as an anti‐obesity tissue in humans
Author(s) -
Chechi K.,
Nedergaard J.,
Richard D.
Publication year - 2014
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1111/obr.12116
Subject(s) - brown adipose tissue , adipose tissue , thermogenesis , obesity , white adipose tissue , biology , medicine , physiology , bioinformatics , endocrinology
Summary During the 11th S tock C onference held in M ontreal, Q uebec, C anada, world‐leading experts came together to present and discuss recent developments made in the field of brown adipose tissue biology. Owing to the vast capacity of brown adipose tissue for burning food energy in the process of thermogenesis, and due to demonstrations of its presence in adult humans, there is tremendous interest in targeting brown adipose tissue as an anti‐obesity tissue in humans. However, the future of such therapeutic approaches relies on our understanding of the origin, development, recruitment, activation and regulation of brown adipose tissue in humans. As reviewed here, the 11th S tock C onference was organized around these themes to discuss the recent progress made in each aspect, to identify gaps in our current understanding and to further provide a common groundwork that could support collaborative efforts aimed at a future therapy for obesity, based on brown adipose tissue thermogenesis.